Assay Detail
Binding
CHEMBL4425326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE5A
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.53 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1671905 | — | — | 1 | 8.92 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.66 |
| CHEMBL168949 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1671905 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL168949 | — | IC50 | = | 10.0 | nM | 8.00 |