Assay Detail
Functional
CHEMBL4425354
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Antiplasmodial activity against chloroquine/antifolate-sensitive Plasmodium falciparum TM4 infected in human RBC incubated for 18 to 20 hrs by microdilution radioisotope method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.40 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.52 |
| CHEMBL747 | CYCLOGUANIL | 2.0 | 1 | 7.40 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.10 |
| CHEMBL382849 | — | — | 1 | 4.96 |
| CHEMBL4440450 | — | — | 1 | 4.71 |
| CHEMBL4577649 | — | — | 1 | 4.59 |
| CHEMBL361803 | — | — | 1 | 4.50 |
| CHEMBL4448123 | — | — | 1 | 4.42 |
| CHEMBL33256 | CHRYSOSPLENOL B | — | 1 | 4.40 |
| CHEMBL4443390 | — | — | 1 | 4.38 |
| CHEMBL4434696 | — | — | 1 | - |
| CHEMBL1970394 | — | — | 1 | - |
| CHEMBL165180 | PACHYPODOL | — | 1 | - |
| CHEMBL361362 | SYRINGARESINOL | — | 1 | - |
| CHEMBL206555 | N-TRANS-FERULOYL TYRAMINE | — | 1 | - |
| CHEMBL206646 | — | — | 1 | - |
| CHEMBL64286 | N-P-COUMAROYL TYRAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL747 | CYCLOGUANIL | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL382849 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4440450 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL4577649 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL361803 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL4448123 | — | IC50 | = | 38100.0 | nM | 4.42 |
| CHEMBL33256 | CHRYSOSPLENOL B | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL4443390 | — | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL4434696 | — | IC50 | > | 47800.0 | nM | - |
| CHEMBL1970394 | — | IC50 | > | 47800.0 | nM | - |
| CHEMBL165180 | PACHYPODOL | IC50 | > | 47800.0 | nM | - |
| CHEMBL361362 | SYRINGARESINOL | IC50 | > | 47800.0 | nM | - |
| CHEMBL206555 | N-TRANS-FERULOYL TYRAMINE | IC50 | > | 47800.0 | nM | - |
| CHEMBL206646 | — | IC50 | > | 47800.0 | nM | - |
| CHEMBL64286 | N-P-COUMAROYL TYRAMINE | IC50 | > | 47800.0 | nM | - |