Assay Detail
Functional
CHEMBL4425355
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Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human RBC incubated for 18 to 20 hrs by microdilution radioisotope method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.85 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.52 |
| CHEMBL747 | CYCLOGUANIL | 2.0 | 1 | 5.50 |
| CHEMBL382849 | — | — | 1 | 5.04 |
| CHEMBL4577649 | — | — | 1 | 4.97 |
| CHEMBL33256 | CHRYSOSPLENOL B | — | 1 | 4.91 |
| CHEMBL206646 | — | — | 1 | 4.62 |
| CHEMBL4448123 | — | — | 1 | 4.58 |
| CHEMBL4440450 | — | — | 1 | 4.58 |
| CHEMBL361803 | — | — | 1 | 4.55 |
| CHEMBL4434696 | — | — | 1 | 4.54 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 4.51 |
| CHEMBL4443390 | — | — | 1 | 4.49 |
| CHEMBL206555 | N-TRANS-FERULOYL TYRAMINE | — | 1 | 4.26 |
| CHEMBL1970394 | — | — | 1 | - |
| CHEMBL165180 | PACHYPODOL | — | 1 | - |
| CHEMBL361362 | SYRINGARESINOL | — | 1 | - |
| CHEMBL64286 | N-P-COUMAROYL TYRAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL747 | CYCLOGUANIL | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL382849 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4577649 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL33256 | CHRYSOSPLENOL B | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL206646 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL4448123 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL4440450 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL361803 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL4434696 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4443390 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL206555 | N-TRANS-FERULOYL TYRAMINE | IC50 | = | 54900.0 | nM | 4.26 |
| CHEMBL1970394 | — | IC50 | > | 47800.0 | nM | - |
| CHEMBL165180 | PACHYPODOL | IC50 | > | 47800.0 | nM | - |
| CHEMBL361362 | SYRINGARESINOL | IC50 | > | 47800.0 | nM | - |
| CHEMBL64286 | N-P-COUMAROYL TYRAMINE | IC50 | > | 47800.0 | nM | - |