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Assay Detail

CHEMBL4425358

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability by MTT assay
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H460
Confidence 1 — Organism
Curated By Autocuration

Target

NCI-H460 (CHEMBL396)
Type CELL-LINE
Organism Homo sapiens

Publication

Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces.
Ding N, Jiang Y, Han L, Chen X, Ma J, Qu X, Mu Y, Liu J, Li L, Jiang C, Huang X.
J Nat Prod (2016) 79 : 799 -805
PubMed 26933756 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.07 6.01
Activity 4 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE 4.0 1 6.01
CHEMBL4447694 1 5.63
CHEMBL4460454 1 5.46
CHEMBL4449338 1 5.30
CHEMBL290814 BAFILOMYCIN A1 1 4.91
CHEMBL299049 1 4.57
CHEMBL4445177 1 4.36
CHEMBL4442158 1 4.30
CHEMBL4539651 1 -
CHEMBL4569883 1 -
CHEMBL4582826 1 -
CHEMBL3315225 1 -
CHEMBL3120650 1 -
CHEMBL4436191 1 -
CHEMBL4538700 1 -
CHEMBL4473839 1 -
CHEMBL293078 BAFILOMYCIN G 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE IC50 = 980.0 nM 6.01
CHEMBL4447694 IC50 = 2340.0 nM 5.63
CHEMBL4460454 IC50 = 3430.0 nM 5.46
CHEMBL4449338 IC50 = 5020.0 nM 5.30
CHEMBL290814 BAFILOMYCIN A1 IC50 = 12410.0 nM 4.91
CHEMBL299049 IC50 = 26700.0 nM 4.57
CHEMBL4445177 IC50 = 44100.0 nM 4.36
CHEMBL4442158 IC50 = 49800.0 nM 4.30
CHEMBL4539651 IC50 > 100000.0 nM -
CHEMBL4569883 Activity - -
CHEMBL4582826 Activity - -
CHEMBL3315225 Activity - -
CHEMBL3120650 Activity - -
CHEMBL4436191 IC50 > 100000.0 nM -
CHEMBL4538700 IC50 > 100000.0 nM -
CHEMBL4473839 IC50 > 100000.0 nM -
CHEMBL293078 BAFILOMYCIN G IC50 > 100000.0 nM -