Assay Detail
Binding
CHEMBL4425527
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Inhibition of ABCB1 in human A2780adr cells preincubated for 30 mins before calcein AM addition by calcein AM assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of 4-Anilino-quinazolines and -quinolines as Inhibitors of Breast Cancer Resistance Protein (ABCG2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.72 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4437626 | — | — | 1 | 6.18 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 5.92 |
| CHEMBL4462578 | — | — | 1 | 5.85 |
| CHEMBL2158554 | — | — | 1 | 5.73 |
| CHEMBL4455303 | — | — | 1 | 5.54 |
| CHEMBL1474597 | — | — | 1 | 5.52 |
| CHEMBL4530796 | — | — | 1 | 5.32 |
| CHEMBL4447490 | — | — | 1 | - |
| CHEMBL120099 | — | — | 1 | - |
| CHEMBL1624741 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4437626 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4462578 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL2158554 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL4455303 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL1474597 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4530796 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL4447490 | — | IC50 | - | — | - | |
| CHEMBL120099 | — | IC50 | - | — | - | |
| CHEMBL1624741 | — | IC50 | - | — | - |