Assay Detail
Binding
CHEMBL4425547
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Staphylococcus aureus FabF C165Q mutant expressed in Escherichia coli BL21 (DE3) PlysS cells by intrinsic tryptophan fluorescence quenching-based fluorimetric method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-oxoacyl-[acyl-carrier-protein] synthase 2 (CHEMBL5341) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 4.43 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4578072 | — | — | 1 | 4.92 |
| CHEMBL4459185 | — | — | 1 | 4.48 |
| CHEMBL4454335 | — | — | 1 | 4.25 |
| CHEMBL399043 | THIOLACTOMYCIN | — | 1 | 4.06 |
| CHEMBL4458874 | — | — | 1 | - |
| CHEMBL4556828 | — | — | 1 | - |
| CHEMBL4569473 | — | — | 1 | - |
| CHEMBL4532925 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4578072 | — | Kd | = | 11900.0 | nM | 4.92 |
| CHEMBL4459185 | — | Kd | = | 33000.0 | nM | 4.48 |
| CHEMBL4454335 | — | Kd | = | 56200.0 | nM | 4.25 |
| CHEMBL399043 | THIOLACTOMYCIN | Kd | = | 88000.0 | nM | 4.06 |
| CHEMBL4458874 | — | Kd | - | — | - | |
| CHEMBL4556828 | — | Kd | - | — | - | |
| CHEMBL4569473 | — | Kd | - | — | - | |
| CHEMBL4532925 | — | Kd | - | — | - |