Assay Detail
Binding
CHEMBL4425560
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MMP2 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Use of Osmotic Pumps to Establish the Pharmacokinetic-Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.31 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358155 | — | — | 1 | 5.75 |
| CHEMBL4587825 | — | — | 1 | 5.62 |
| CHEMBL3358156 | — | — | 1 | 5.50 |
| CHEMBL4589438 | — | — | 1 | 5.46 |
| CHEMBL4097165 | — | — | 1 | 5.24 |
| CHEMBL3358158 | — | — | 1 | 4.96 |
| CHEMBL4450729 | — | — | 1 | 4.96 |
| CHEMBL4436740 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358155 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4587825 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3358156 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4589438 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4097165 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3358158 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4450729 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4436740 | — | IC50 | = | 11000.0 | nM | 4.96 |