Assay Detail
Binding
CHEMBL4425565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MMP14 using Mca-PQGL-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-AR-OH as substrate measured after 2 to 4 hrs by fluorescence analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Use of Osmotic Pumps to Establish the Pharmacokinetic-Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.51 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097165 | — | — | 1 | 5.12 |
| CHEMBL3358155 | — | — | 1 | 5.06 |
| CHEMBL4587825 | — | — | 1 | 4.58 |
| CHEMBL4589438 | — | — | 1 | 4.47 |
| CHEMBL3358156 | — | — | 1 | 4.43 |
| CHEMBL4436740 | — | — | 1 | 4.24 |
| CHEMBL4450729 | — | — | 1 | 4.11 |
| CHEMBL3358158 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097165 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3358155 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4587825 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4589438 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL3358156 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4436740 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4450729 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL3358158 | — | IC50 | = | 86000.0 | nM | 4.07 |