Assay Detail
Functional
CHEMBL4425667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human ES2 cells after 24 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.15 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572582 | — | — | 1 | 8.15 |
| CHEMBL4452015 | — | — | 1 | 8.15 |
| CHEMBL4470842 | — | — | 1 | 8.15 |
| CHEMBL4580276 | — | — | 1 | 8.15 |
| CHEMBL4585086 | — | — | 1 | 8.15 |
| CHEMBL4538421 | — | — | 1 | 8.15 |
| CHEMBL4516562 | — | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572582 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4452015 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4470842 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4580276 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4585086 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4538421 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4516562 | — | IC50 | = | 7.0 | nM | 8.15 |