Assay Detail
Binding
CHEMBL4425876
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Inhibition of recombinant NAMPT (unknown origin) using nicotinamide as substrate measured every 5 mins for 30 mins in presence of recombinant NMNAT1
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Design of Potent Nicotinamide Phosphoribosyltransferase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.67 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4544378 | — | — | 1 | 7.60 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 7.50 |
| CHEMBL4437678 | — | — | 1 | 7.28 |
| CHEMBL4467850 | — | — | 1 | 7.26 |
| CHEMBL4445749 | — | — | 1 | 7.17 |
| CHEMBL4436777 | — | — | 1 | 7.08 |
| CHEMBL4443275 | — | — | 1 | 7.00 |
| CHEMBL4573977 | — | — | 1 | 6.92 |
| CHEMBL4516235 | — | — | 1 | 6.83 |
| CHEMBL4552050 | — | — | 1 | 6.74 |
| CHEMBL4544855 | — | — | 1 | 6.71 |
| CHEMBL4585844 | — | — | 1 | 6.67 |
| CHEMBL4458686 | — | — | 1 | 6.54 |
| CHEMBL4439790 | — | — | 1 | 6.44 |
| CHEMBL4466939 | — | — | 1 | 6.42 |
| CHEMBL4519620 | — | — | 1 | 6.26 |
| CHEMBL4518730 | — | — | 1 | 6.15 |
| CHEMBL4456190 | — | — | 1 | 6.15 |
| CHEMBL4457097 | — | — | 1 | 6.11 |
| CHEMBL4436253 | — | — | 1 | 6.06 |
| CHEMBL4455440 | — | — | 1 | 6.00 |
| CHEMBL4589960 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4544378 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4437678 | — | IC50 | = | 52.7 | nM | 7.28 |
| CHEMBL4467850 | — | IC50 | = | 54.8 | nM | 7.26 |
| CHEMBL4445749 | — | IC50 | = | 66.9 | nM | 7.17 |
| CHEMBL4436777 | — | IC50 | = | 82.5 | nM | 7.08 |
| CHEMBL4443275 | — | IC50 | = | 99.6 | nM | 7.00 |
| CHEMBL4573977 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4516235 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL4552050 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL4544855 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4585844 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL4458686 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL4439790 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL4466939 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL4519620 | — | IC50 | = | 544.0 | nM | 6.26 |
| CHEMBL4518730 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL4456190 | — | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL4457097 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4436253 | — | IC50 | = | 873.0 | nM | 6.06 |
| CHEMBL4455440 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4589960 | — | IC50 | = | 1410.0 | nM | 5.85 |