Assay Detail
Binding
CHEMBL4426075
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Binding affinity to human plasmin assessed as slow binding constant in presence of Mes-DArg-Phe-Arg-AMC after 20 mins by Dixon plot analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of Cyclic Plasmin Inhibitors: From Benzamidines to Benzylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.38 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4458743 | — | — | 1 | 9.82 |
| CHEMBL4454130 | — | — | 1 | 9.38 |
| CHEMBL4553652 | — | — | 1 | 9.37 |
| CHEMBL4560508 | — | — | 1 | 9.27 |
| CHEMBL4515955 | — | — | 1 | 9.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4458743 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL4454130 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL4553652 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL4560508 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL4515955 | — | Ki | = | 0.85 | nM | 9.07 |