Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4426077

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Plasminogen (CHEMBL1801)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Optimization of Cyclic Plasmin Inhibitors: From Benzamidines to Benzylamines.
Hinkes S, Wuttke A, Saupe SM, Ivanova T, Wagner S, Knörlein A, Heine A, Klebe G, Steinmetzer T.
J Med Chem (2016) 59 : 6370 -6386
PubMed 27280436 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 8.46 10.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4476141 1 10.15
CHEMBL4458743 1 9.89
CHEMBL4454130 1 9.49
CHEMBL4591922 1 9.35
CHEMBL4571212 1 9.29
CHEMBL4553652 1 9.28
CHEMBL4560508 1 9.25
CHEMBL4515955 1 9.11
CHEMBL4545331 1 9.11
CHEMBL4437656 1 8.92
CHEMBL4476627 1 8.57
CHEMBL4443405 1 8.43
CHEMBL4441842 1 8.41
CHEMBL4458773 1 8.28
CHEMBL4466850 1 8.23
CHEMBL4519782 1 8.10
CHEMBL4547050 1 7.89
CHEMBL4472791 1 7.71
CHEMBL4466116 1 7.64
CHEMBL4583612 1 7.30
CHEMBL4577240 1 7.21
CHEMBL4441722 1 7.18
CHEMBL4444049 1 7.12
CHEMBL4549153 1 7.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4476141 Ki = 0.07 nM 10.15
CHEMBL4458743 Ki = 0.13 nM 9.89
CHEMBL4454130 Ki = 0.32 nM 9.49
CHEMBL4591922 Ki = 0.45 nM 9.35
CHEMBL4571212 Ki = 0.51 nM 9.29
CHEMBL4553652 Ki = 0.52 nM 9.28
CHEMBL4560508 Ki = 0.56 nM 9.25
CHEMBL4515955 Ki = 0.77 nM 9.11
CHEMBL4545331 Ki = 0.77 nM 9.11
CHEMBL4437656 Ki = 1.2 nM 8.92
CHEMBL4476627 Ki = 2.69 nM 8.57
CHEMBL4443405 Ki = 3.7 nM 8.43
CHEMBL4441842 Ki = 3.93 nM 8.41
CHEMBL4458773 Ki = 5.2 nM 8.28
CHEMBL4466850 Ki = 5.9 nM 8.23
CHEMBL4519782 Ki = 8.0 nM 8.10
CHEMBL4547050 Ki = 12.8 nM 7.89
CHEMBL4472791 Ki = 19.7 nM 7.71
CHEMBL4466116 Ki = 22.7 nM 7.64
CHEMBL4583612 Ki = 50.6 nM 7.30
CHEMBL4577240 Ki = 61.1 nM 7.21
CHEMBL4441722 Ki = 66.3 nM 7.18
CHEMBL4444049 Ki = 75.3 nM 7.12
CHEMBL4549153 Ki = 81.3 nM 7.09