Assay Detail
Binding
CHEMBL4426113
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Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.84 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4476084 | — | — | 1 | 7.08 |
| CHEMBL4460933 | — | — | 1 | 6.74 |
| CHEMBL4525566 | — | — | 1 | 6.39 |
| CHEMBL4545838 | — | — | 1 | 6.23 |
| CHEMBL4532693 | — | — | 1 | 6.23 |
| CHEMBL4459118 | — | — | 1 | 6.10 |
| CHEMBL4583920 | — | — | 1 | 6.08 |
| CHEMBL4456743 | — | — | 1 | 6.04 |
| CHEMBL4472777 | — | — | 1 | 6.04 |
| CHEMBL4584482 | — | — | 1 | 5.83 |
| CHEMBL4583482 | — | — | 1 | 5.64 |
| CHEMBL4471505 | — | — | 1 | 5.41 |
| CHEMBL4572367 | — | — | 1 | 5.33 |
| CHEMBL4520060 | — | — | 1 | 5.22 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 5.22 |
| CHEMBL4538817 | — | — | 1 | 5.16 |
| CHEMBL4469914 | — | — | 1 | 5.16 |
| CHEMBL4561872 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4476084 | — | Ki | = | 82.9 | nM | 7.08 |
| CHEMBL4460933 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL4525566 | — | Ki | = | 411.0 | nM | 6.39 |
| CHEMBL4545838 | — | Ki | = | 593.0 | nM | 6.23 |
| CHEMBL4532693 | — | Ki | = | 589.0 | nM | 6.23 |
| CHEMBL4459118 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL4583920 | — | Ki | = | 837.0 | nM | 6.08 |
| CHEMBL4456743 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL4472777 | — | Ki | = | 908.0 | nM | 6.04 |
| CHEMBL4584482 | — | Ki | = | 1480.0 | nM | 5.83 |
| CHEMBL4583482 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL4471505 | — | Ki | = | 3925.0 | nM | 5.41 |
| CHEMBL4572367 | — | Ki | = | 4670.0 | nM | 5.33 |
| CHEMBL4520060 | — | Ki | = | 6020.0 | nM | 5.22 |
| CHEMBL310671 | SACCHARIN | Ki | = | 5950.0 | nM | 5.22 |
| CHEMBL4538817 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL4469914 | — | Ki | = | 6945.0 | nM | 5.16 |
| CHEMBL4561872 | — | Ki | = | 7270.0 | nM | 5.14 |