Assay Detail
Binding
CHEMBL4426115
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Inhibition of human carbonic anhydrase 9 catalytic site preincubated for 15 mins by stopped flow CO2 hydration assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.78 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4538817 | — | — | 1 | 7.57 |
| CHEMBL4584482 | — | — | 1 | 7.52 |
| CHEMBL4545838 | — | — | 1 | 7.51 |
| CHEMBL4471505 | — | — | 1 | 7.50 |
| CHEMBL4532693 | — | — | 1 | 7.17 |
| CHEMBL4459118 | — | — | 1 | 7.13 |
| CHEMBL4583482 | — | — | 1 | 7.06 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.99 |
| CHEMBL4469914 | — | — | 1 | 6.69 |
| CHEMBL4561872 | — | — | 1 | 6.66 |
| CHEMBL4460933 | — | — | 1 | 6.65 |
| CHEMBL4476084 | — | — | 1 | 6.64 |
| CHEMBL4520060 | — | — | 1 | 6.63 |
| CHEMBL4525566 | — | — | 1 | 6.27 |
| CHEMBL4472777 | — | — | 1 | 6.26 |
| CHEMBL4583920 | — | — | 1 | 6.18 |
| CHEMBL4456743 | — | — | 1 | 5.93 |
| CHEMBL4572367 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4538817 | — | Ki | = | 27.2 | nM | 7.57 |
| CHEMBL4584482 | — | Ki | = | 30.4 | nM | 7.52 |
| CHEMBL4545838 | — | Ki | = | 31.2 | nM | 7.51 |
| CHEMBL4471505 | — | Ki | = | 31.5 | nM | 7.50 |
| CHEMBL4532693 | — | Ki | = | 67.9 | nM | 7.17 |
| CHEMBL4459118 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL4583482 | — | Ki | = | 86.2 | nM | 7.06 |
| CHEMBL310671 | SACCHARIN | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL4469914 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL4561872 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL4460933 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL4476084 | — | Ki | = | 231.0 | nM | 6.64 |
| CHEMBL4520060 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL4525566 | — | Ki | = | 539.0 | nM | 6.27 |
| CHEMBL4472777 | — | Ki | = | 543.0 | nM | 6.26 |
| CHEMBL4583920 | — | Ki | = | 665.0 | nM | 6.18 |
| CHEMBL4456743 | — | Ki | = | 1186.0 | nM | 5.93 |
| CHEMBL4572367 | — | Ki | = | 1920.0 | nM | 5.72 |