Assay Detail
Binding
CHEMBL4426116
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Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.98 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572367 | — | — | 1 | 8.06 |
| CHEMBL4469914 | — | — | 1 | 8.05 |
| CHEMBL4561872 | — | — | 1 | 8.03 |
| CHEMBL4538817 | — | — | 1 | 7.45 |
| CHEMBL4532693 | — | — | 1 | 7.41 |
| CHEMBL4471505 | — | — | 1 | 7.38 |
| CHEMBL4459118 | — | — | 1 | 7.28 |
| CHEMBL4545838 | — | — | 1 | 7.23 |
| CHEMBL4476084 | — | — | 1 | 7.12 |
| CHEMBL4583482 | — | — | 1 | 7.11 |
| CHEMBL4456743 | — | — | 1 | 7.05 |
| CHEMBL4520060 | — | — | 1 | 6.38 |
| CHEMBL4583920 | — | — | 1 | 6.34 |
| CHEMBL4472777 | — | — | 1 | 6.27 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.20 |
| CHEMBL4584482 | — | — | 1 | 6.17 |
| CHEMBL4525566 | — | — | 1 | 6.09 |
| CHEMBL4460933 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572367 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL4469914 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL4561872 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL4538817 | — | Ki | = | 35.9 | nM | 7.45 |
| CHEMBL4532693 | — | Ki | = | 38.7 | nM | 7.41 |
| CHEMBL4471505 | — | Ki | = | 41.4 | nM | 7.38 |
| CHEMBL4459118 | — | Ki | = | 52.6 | nM | 7.28 |
| CHEMBL4545838 | — | Ki | = | 58.9 | nM | 7.23 |
| CHEMBL4476084 | — | Ki | = | 76.8 | nM | 7.12 |
| CHEMBL4583482 | — | Ki | = | 78.5 | nM | 7.11 |
| CHEMBL4456743 | — | Ki | = | 89.8 | nM | 7.05 |
| CHEMBL4520060 | — | Ki | = | 413.0 | nM | 6.38 |
| CHEMBL4583920 | — | Ki | = | 459.0 | nM | 6.34 |
| CHEMBL4472777 | — | Ki | = | 537.0 | nM | 6.27 |
| CHEMBL310671 | SACCHARIN | Ki | = | 633.0 | nM | 6.20 |
| CHEMBL4584482 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL4525566 | — | Ki | = | 804.0 | nM | 6.09 |
| CHEMBL4460933 | — | Ki | = | 910.0 | nM | 6.04 |