Assay Detail
Binding
CHEMBL4426199
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Agonist activity at human S1P1 receptor expressed in CHO cell membranes measured after 45 mins by [35S]GTP-gammaS binding assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.83 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473672 | — | — | 1 | 8.96 |
| CHEMBL4458575 | — | — | 1 | 8.92 |
| CHEMBL4529165 | — | — | 1 | 8.64 |
| CHEMBL4476492 | — | — | 1 | 8.62 |
| CHEMBL4448752 | — | — | 1 | 8.46 |
| CHEMBL4522539 | — | — | 1 | 8.41 |
| CHEMBL4457691 | — | — | 1 | 8.41 |
| CHEMBL4474984 | — | — | 1 | 8.38 |
| CHEMBL4587424 | — | — | 1 | 8.16 |
| CHEMBL4520384 | — | — | 1 | 8.11 |
| CHEMBL4545842 | — | — | 1 | 8.11 |
| CHEMBL4461520 | — | — | 1 | 8.11 |
| CHEMBL4474880 | — | — | 1 | 8.01 |
| CHEMBL4553789 | — | — | 1 | 7.96 |
| CHEMBL4437944 | — | — | 1 | 7.92 |
| CHEMBL4541678 | — | — | 1 | 7.66 |
| CHEMBL4469843 | — | — | 1 | 7.57 |
| CHEMBL4521128 | — | — | 1 | 7.52 |
| CHEMBL4464631 | — | — | 1 | 7.47 |
| CHEMBL4569675 | — | — | 1 | 7.42 |
| CHEMBL4440968 | — | — | 1 | 7.21 |
| CHEMBL4475594 | — | — | 1 | 7.19 |
| CHEMBL4553920 | — | — | 1 | 7.02 |
| CHEMBL4553546 | — | — | 1 | 6.96 |
| CHEMBL4574665 | — | — | 1 | 6.89 |
| CHEMBL4473311 | — | — | 1 | 6.77 |
| CHEMBL4458762 | — | — | 1 | 6.64 |
| CHEMBL4452807 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473672 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4458575 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4529165 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4476492 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4448752 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4522539 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4457691 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4474984 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4587424 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4520384 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4545842 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4461520 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4474880 | — | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4553789 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4437944 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4541678 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4469843 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4521128 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4464631 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4569675 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4440968 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4475594 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4553920 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4553546 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4574665 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4473311 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4458762 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4452807 | — | EC50 | - | — | - |