Assay Detail
Binding
CHEMBL4426319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 125I-ET1 from pig ETB receptor transfected in grivet COS7 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.39 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4451582 | — | — | 1 | 9.07 |
| CHEMBL54057 | — | — | 1 | 8.70 |
| CHEMBL112624 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4451582 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL54057 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL112624 | — | IC50 | = | 41.0 | nM | 7.39 |