Assay Detail
Binding
CHEMBL4426405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human VEGFR2 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Substituted 1H-Pyrazolo[3,4-b]pyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.62 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 7.17 |
| CHEMBL4469836 | — | — | 1 | 6.44 |
| CHEMBL4437058 | — | — | 1 | 6.26 |
| CHEMBL4562845 | — | — | 1 | - |
| CHEMBL4580145 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 67.2 | nM | 7.17 |
| CHEMBL4469836 | — | IC50 | = | 365.9 | nM | 6.44 |
| CHEMBL4437058 | — | IC50 | = | 548.4 | nM | 6.26 |
| CHEMBL4562845 | — | IC50 | - | — | - | |
| CHEMBL4580145 | — | IC50 | - | — | - |