Assay Detail
Binding
CHEMBL4426449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MEK in human A375 cells assessed as inhibition of ERK phosphorylation
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Dual specificity mitogen-activated protein kinase kinase; MEK1/2 (CHEMBL2111289) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.05 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3590107 | — | — | 1 | 8.05 |
| CHEMBL2408789 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3590107 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2408789 | — | IC50 | > | 10000.0 | nM | - |