Assay Detail
Binding
CHEMBL4426523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 6-Amino-9-(2-carboxy-4-((6-(4-(4-(4-(4-(3-carboxy-6-(4-(trifluoromethyl)phenyl)-naphthalen-1-yl)phenyl)piperidin-1-yl)-butyl)-1H-1,2,3-triazol-1-yl)hexyl)carbamoyl)-phenyl)-3-iminio-5-sulfo-3H-xanthene-4-sulfonate from human P2Y14R expressed in CHO cells measured after 15 mins by flow cytometric analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.94 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1800685 | PPTN | — | 1 | 8.22 |
| CHEMBL4454538 | — | — | 1 | 7.50 |
| CHEMBL4441075 | — | — | 1 | 7.14 |
| CHEMBL4472517 | — | — | 1 | 7.04 |
| CHEMBL4465763 | — | — | 1 | 6.94 |
| CHEMBL4458050 | — | — | 1 | 6.88 |
| CHEMBL4587611 | — | — | 1 | 6.79 |
| CHEMBL4462380 | — | — | 1 | 6.65 |
| CHEMBL4568641 | — | — | 1 | 6.64 |
| CHEMBL4443391 | — | — | 1 | 6.62 |
| CHEMBL4554777 | — | — | 1 | 6.54 |
| CHEMBL4558911 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1800685 | PPTN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4454538 | — | IC50 | = | 31.7 | nM | 7.50 |
| CHEMBL4441075 | — | IC50 | = | 72.4 | nM | 7.14 |
| CHEMBL4472517 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4465763 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL4458050 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL4587611 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4462380 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL4568641 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL4443391 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL4554777 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4558911 | — | IC50 | = | 481.0 | nM | 6.32 |