Assay Detail
Functional
CHEMBL4426602
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Cytotoxicity against triapine-resistant human SW480 cells incubated for 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.94 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4545491 | — | — | 1 | 7.52 |
| CHEMBL385064 | — | — | 1 | 6.70 |
| CHEMBL4446576 | — | — | 1 | 6.52 |
| CHEMBL4447179 | — | — | 1 | 6.52 |
| CHEMBL4562857 | — | — | 1 | 5.54 |
| CHEMBL4452153 | — | — | 1 | 5.34 |
| CHEMBL4577257 | — | — | 1 | 5.32 |
| CHEMBL4567077 | — | — | 1 | 5.02 |
| CHEMBL4453724 | — | — | 1 | 5.00 |
| CHEMBL231616 | TRIAPINE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4545491 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL385064 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4446576 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4447179 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4562857 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4452153 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4577257 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4567077 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4453724 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL231616 | TRIAPINE | IC50 | > | 50000.0 | nM | - |