Assay Detail
Functional
CHEMBL4426630
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Antiviral activity against Influenza A virus (A/Moscow/10/99(H3N2)) expressing A/Puerto Rico/8/34(H1N1) genes infected in MDCK cells assessed as reduction in viral replication after 72 hrs by hemagglutination test
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.12 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4549718 | — | — | 1 | 8.46 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.15 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.75 |
| CHEMBL4458513 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4549718 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 17.7 | nM | 7.75 |
| CHEMBL4458513 | — | EC50 | - | — | - |