Assay Detail
Binding
CHEMBL4426656
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Inhibition of human recombinant MAOA expressed in microsomes of baculovirus-infected insect cell using kynuramine as substrate preincubated for 20 mins followed by protein addition measured after 30 mins by fluorescence assay
29
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.71 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.60 |
| CHEMBL4527319 | — | — | 1 | 6.68 |
| CHEMBL4460538 | — | — | 2 | 6.27 |
| CHEMBL4539659 | — | — | 1 | 6.16 |
| CHEMBL4443825 | — | — | 1 | 6.09 |
| CHEMBL4446787 | — | — | 1 | 6.08 |
| CHEMBL4466718 | — | — | 1 | 6.06 |
| CHEMBL4447506 | — | — | 1 | 6.01 |
| CHEMBL4439320 | — | — | 1 | 5.96 |
| CHEMBL4474935 | — | — | 1 | 5.89 |
| CHEMBL4454278 | — | — | 1 | 5.80 |
| CHEMBL4556552 | — | — | 1 | 5.76 |
| CHEMBL4564297 | — | — | 1 | 5.71 |
| CHEMBL4562275 | — | — | 1 | 5.65 |
| CHEMBL4571763 | — | — | 2 | 5.64 |
| CHEMBL4472789 | — | — | 1 | 5.62 |
| CHEMBL4522235 | — | — | 1 | 5.57 |
| CHEMBL4456665 | — | — | 1 | 5.55 |
| CHEMBL4569054 | — | — | 1 | 5.45 |
| CHEMBL4455029 | — | — | 1 | 5.35 |
| CHEMBL4441966 | — | — | 1 | 5.03 |
| CHEMBL4582505 | — | — | 1 | 5.00 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | 4.96 |
| CHEMBL4441456 | — | — | 1 | 4.93 |
| CHEMBL4473562 | — | — | 1 | 4.91 |
| CHEMBL4451548 | — | — | 1 | 4.78 |
| CHEMBL4466478 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4527319 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4460538 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4539659 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4443825 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4446787 | — | IC50 | = | 822.0 | nM | 6.08 |
| CHEMBL4466718 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4447506 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4439320 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4460538 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4474935 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL4454278 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4556552 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4564297 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4562275 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL4571763 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4472789 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL4522235 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL4456665 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL4569054 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL4571763 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL4455029 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL4441966 | — | IC50 | = | 9330.0 | nM | 5.03 |
| CHEMBL4582505 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL673 | PARGYLINE | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4441456 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4473562 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4451548 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL4466478 | — | IC50 | = | 23900.0 | nM | 4.62 |