Assay Detail
Functional
CHEMBL4426862
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Agonist activity at rat CB1 receptor expressed in HEK293 cells assessed as decrease in forskolin-stimulated cAMP levels after 30 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel C-Ring-Hydroxy-Substituted Controlled Deactivation Cannabinergic Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.34 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4470925 | — | — | 1 | 8.60 |
| CHEMBL4475022 | — | — | 1 | 8.34 |
| CHEMBL4465566 | — | — | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4470925 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4475022 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4465566 | — | EC50 | = | 8.6 | nM | 8.07 |