Assay Detail
Binding
CHEMBL4427018
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Inhibition of DAGLalpha in mouse brain proteome pre-incubated for 30 mins followed by ABP MB064 probe addition for 15 mins by ABPP assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Subcellular | Proteome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.93 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447844 | — | — | 1 | 7.60 |
| CHEMBL3319620 | — | — | 1 | 6.90 |
| CHEMBL175854 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447844 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3319620 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL175854 | — | IC50 | = | 501.19 | nM | 6.30 |