Assay Detail
Functional
CHEMBL4427074
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Antischistosomal activity against Schistosoma mansoni BH schistosomula assessed as inhibition of parasite motility after 48 hrs by HCS microscopic analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Schistosoma mansoni |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.60 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL976 | PRAZIQUANTEL | 4.0 | 1 | 5.72 |
| CHEMBL4522839 | — | — | 1 | 5.58 |
| CHEMBL1380406 | — | — | 1 | 5.49 |
| CHEMBL594404 | — | — | 1 | - |
| CHEMBL4534899 | — | — | 1 | - |
| CHEMBL4556222 | — | — | 1 | - |
| CHEMBL1455317 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL976 | PRAZIQUANTEL | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4522839 | — | EC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL1380406 | — | EC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL594404 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4534899 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4556222 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL1455317 | — | EC50 | > | 20000.0 | nM | - |