Assay Detail
Functional
CHEMBL4427099
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Cytotoxicity against human A549 cells assessed as inhibition of cell growth after 48 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of N(9)-substituted harmine derivatives as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.32 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475611 | — | — | 1 | 6.32 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.12 |
| CHEMBL4531845 | — | — | 1 | 6.08 |
| CHEMBL4562365 | — | — | 1 | 6.06 |
| CHEMBL4572266 | — | — | 1 | 5.90 |
| CHEMBL4461860 | — | — | 1 | 5.88 |
| CHEMBL4536685 | — | — | 1 | 5.55 |
| CHEMBL4524787 | — | — | 1 | 5.41 |
| CHEMBL4455026 | — | — | 1 | 5.32 |
| CHEMBL4516344 | — | — | 1 | 5.32 |
| CHEMBL4545875 | — | — | 1 | 5.31 |
| CHEMBL44889 | — | — | 1 | 5.30 |
| CHEMBL4458977 | — | — | 1 | 5.25 |
| CHEMBL325351 | — | — | 1 | 5.21 |
| CHEMBL4460668 | — | — | 1 | 5.20 |
| CHEMBL4566715 | — | — | 1 | 5.13 |
| CHEMBL4555077 | — | — | 1 | 5.08 |
| CHEMBL4440995 | — | — | 1 | 5.06 |
| CHEMBL4448233 | — | — | 1 | 5.06 |
| CHEMBL4460242 | — | — | 1 | 5.01 |
| CHEMBL4462226 | — | — | 1 | 4.91 |
| CHEMBL4472205 | — | — | 1 | 4.83 |
| CHEMBL4563623 | — | — | 1 | 4.74 |
| CHEMBL109269 | — | — | 1 | 4.58 |
| CHEMBL269538 | HARMINE | 1.0 | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475611 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4531845 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4562365 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4572266 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4461860 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4536685 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL4524787 | — | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL4455026 | — | IC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL4516344 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4545875 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL44889 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL4458977 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL325351 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL4460668 | — | IC50 | = | 6370.0 | nM | 5.20 |
| CHEMBL4566715 | — | IC50 | = | 7490.0 | nM | 5.13 |
| CHEMBL4555077 | — | IC50 | = | 8340.0 | nM | 5.08 |
| CHEMBL4440995 | — | IC50 | = | 8730.0 | nM | 5.06 |
| CHEMBL4448233 | — | IC50 | = | 8730.0 | nM | 5.06 |
| CHEMBL4460242 | — | IC50 | = | 9660.0 | nM | 5.01 |
| CHEMBL4462226 | — | IC50 | = | 12190.0 | nM | 4.91 |
| CHEMBL4472205 | — | IC50 | = | 14610.0 | nM | 4.83 |
| CHEMBL4563623 | — | IC50 | = | 18390.0 | nM | 4.74 |
| CHEMBL109269 | — | IC50 | = | 26350.0 | nM | 4.58 |
| CHEMBL269538 | HARMINE | IC50 | = | 42250.0 | nM | 4.37 |