Assay Detail
Functional
CHEMBL4427138
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Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic prenylated flavones from the stem and root bark of Daphne giraldii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.67 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447609 | — | — | 1 | 5.27 |
| CHEMBL4551374 | — | — | 1 | 4.74 |
| CHEMBL464006 | MORUSIN | — | 1 | 4.62 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.61 |
| CHEMBL4466409 | — | — | 1 | 4.60 |
| CHEMBL4565640 | — | — | 1 | 4.17 |
| CHEMBL312750 | EUPATILIN | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447609 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL4551374 | — | IC50 | = | 18360.0 | nM | 4.74 |
| CHEMBL464006 | MORUSIN | IC50 | = | 24090.0 | nM | 4.62 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 24660.0 | nM | 4.61 |
| CHEMBL4466409 | — | IC50 | = | 24980.0 | nM | 4.60 |
| CHEMBL4565640 | — | IC50 | = | 66760.0 | nM | 4.17 |
| CHEMBL312750 | EUPATILIN | IC50 | > | 100000.0 | nM | - |