Assay Detail
Binding
CHEMBL4427214
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human P2X3 receptor expressed in HEK293 cells assessed as inhibition of alpha-beta-methylene-ATP induced calcium release measured at 0.1 to 3 secs interval by fluo-4 dye based FLIPR assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New P2X3 receptor antagonists. Part 2: Identification and SAR of quinazolinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3732768 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3732768 | — | IC50 | = | 10.0 | nM | 8.00 |