Assay Detail
Binding
CHEMBL4427587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellmans method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.54 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.00 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.62 |
| CHEMBL3747910 | — | — | 1 | 5.71 |
| CHEMBL3747906 | — | — | 1 | 5.62 |
| CHEMBL3747909 | — | — | 1 | 5.56 |
| CHEMBL3747904 | — | — | 1 | 5.42 |
| CHEMBL3747907 | — | — | 1 | 5.41 |
| CHEMBL3747902 | — | — | 1 | 5.41 |
| CHEMBL3747908 | — | — | 1 | 5.35 |
| CHEMBL3747900 | — | — | 1 | 5.32 |
| CHEMBL3747905 | — | — | 1 | 5.31 |
| CHEMBL3747898 | — | — | 1 | 5.27 |
| CHEMBL3747903 | — | — | 1 | 5.27 |
| CHEMBL3747896 | — | — | 1 | 5.21 |
| CHEMBL3747897 | — | — | 1 | 5.14 |
| CHEMBL4452966 | — | — | 1 | 5.10 |
| CHEMBL3747901 | — | — | 1 | 5.09 |
| CHEMBL3747895 | — | — | 1 | 4.73 |
| CHEMBL3747892 | — | — | 1 | 4.63 |
| CHEMBL3747894 | — | — | 1 | - |
| CHEMBL3747893 | — | — | 1 | - |
| CHEMBL3747899 | — | — | 1 | - |
| CHEMBL3747891 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL95 | TACRINE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3747910 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL3747906 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL3747909 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL3747904 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3747907 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL3747902 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL3747908 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL3747900 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3747905 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3747898 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3747903 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL3747896 | — | IC50 | = | 6220.0 | nM | 5.21 |
| CHEMBL3747897 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL4452966 | — | IC50 | = | 7910.0 | nM | 5.10 |
| CHEMBL3747901 | — | IC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL3747895 | — | IC50 | = | 18570.0 | nM | 4.73 |
| CHEMBL3747892 | — | IC50 | = | 23610.0 | nM | 4.63 |
| CHEMBL3747894 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3747893 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3747899 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3747891 | — | IC50 | > | 10000.0 | nM | - |