Assay Detail
Binding
CHEMBL4427757
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Inhibition of human IDO1 transfected in HEK293T cells assessed as kynurenine formation using L-Trp as substrate after 7 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.53 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2148074 | — | — | 1 | 7.05 |
| CHEMBL4465170 | — | — | 1 | 4.00 |
| CHEMBL4583135 | — | — | 1 | - |
| CHEMBL4467714 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2148074 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4465170 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4583135 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4467714 | — | IC50 | = | 105000.0 | nM | - |