Assay Detail
Binding
CHEMBL4427800
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysis
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.26 | 7.41 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4468555 | — | — | 2 | 7.41 |
| CHEMBL4515745 | — | — | 2 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4468555 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4515745 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4515745 | — | Inhibition | - | % | - | |
| CHEMBL4468555 | — | Inhibition | - | % | - |