Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4428216

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer.
Ai Y, Zhu B, Ren C, Kang F, Li J, Huang Z, Lai Y, Peng S, Ding K, Tian J, Zhang Y.
J Med Chem (2016) 59 : 1747 -1760
PubMed 26891099 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.25 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4475597 1 5.80
CHEMBL4451948 1 5.66
CHEMBL4521088 1 5.54
CHEMBL4442682 1 5.51
CHEMBL4557225 1 5.50
CHEMBL4541862 1 5.48
CHEMBL4541266 1 5.46
CHEMBL4458105 1 5.42
CHEMBL4526106 1 5.40
CHEMBL4445793 1 5.37
CHEMBL4582307 1 5.37
CHEMBL4465438 1 5.35
CHEMBL4437072 1 5.32
CHEMBL4469565 1 5.23
CHEMBL4464149 1 5.17
CHEMBL4439442 1 5.15
CHEMBL4593192 1 5.02
CHEMBL4463300 1 4.93
CHEMBL4437453 1 4.91
CHEMBL4518879 1 4.80
CHEMBL4449505 1 4.76
CHEMBL140 CURCUMIN 3.0 1 4.42
CHEMBL303697 LIGUSTRAZINE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4475597 IC50 = 1600.0 nM 5.80
CHEMBL4451948 IC50 = 2190.0 nM 5.66
CHEMBL4521088 IC50 = 2850.0 nM 5.54
CHEMBL4442682 IC50 = 3070.0 nM 5.51
CHEMBL4557225 IC50 = 3200.0 nM 5.50
CHEMBL4541862 IC50 = 3300.0 nM 5.48
CHEMBL4541266 IC50 = 3500.0 nM 5.46
CHEMBL4458105 IC50 = 3790.0 nM 5.42
CHEMBL4526106 IC50 = 4010.0 nM 5.40
CHEMBL4445793 IC50 = 4300.0 nM 5.37
CHEMBL4582307 IC50 = 4300.0 nM 5.37
CHEMBL4465438 IC50 = 4500.0 nM 5.35
CHEMBL4437072 IC50 = 4780.0 nM 5.32
CHEMBL4469565 IC50 = 5900.0 nM 5.23
CHEMBL4464149 IC50 = 6700.0 nM 5.17
CHEMBL4439442 IC50 = 7100.0 nM 5.15
CHEMBL4593192 IC50 = 9600.0 nM 5.02
CHEMBL4463300 IC50 = 11700.0 nM 4.93
CHEMBL4437453 IC50 = 12310.0 nM 4.91
CHEMBL4518879 IC50 = 15800.0 nM 4.80
CHEMBL4449505 IC50 = 17330.0 nM 4.76
CHEMBL140 CURCUMIN IC50 = 38120.0 nM 4.42
CHEMBL303697 LIGUSTRAZINE IC50 > 200000.0 nM -