Assay Detail
Binding
CHEMBL4428283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of polymerase activity of HIV1 reverse transcriptase using poly(rA)-oligo(dT)16 and [3H]-TTP incubated for 20 mins by liquid scintillation spectrometry
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 66 | 5.50 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474029 | — | — | 1 | 6.47 |
| CHEMBL4461191 | — | — | 1 | 6.10 |
| CHEMBL4550191 | — | — | 1 | 6.09 |
| CHEMBL4466368 | — | — | 1 | 6.08 |
| CHEMBL4291913 | — | — | 1 | 6.07 |
| CHEMBL4288759 | — | — | 1 | 6.07 |
| CHEMBL4455962 | — | — | 1 | 6.00 |
| CHEMBL4454510 | — | — | 1 | 5.77 |
| CHEMBL4281296 | — | — | 1 | 5.70 |
| CHEMBL4453169 | — | — | 1 | 5.51 |
| CHEMBL4475877 | — | — | 1 | 5.50 |
| CHEMBL4438393 | — | — | 1 | 5.48 |
| CHEMBL4472917 | — | — | 1 | 5.44 |
| CHEMBL4438951 | — | — | 1 | 5.30 |
| CHEMBL4473298 | — | — | 1 | 5.30 |
| CHEMBL4563882 | — | — | 1 | 5.24 |
| CHEMBL4549947 | — | — | 1 | 5.24 |
| CHEMBL4514889 | — | — | 1 | 5.20 |
| CHEMBL4451895 | — | — | 1 | 5.20 |
| CHEMBL4443953 | — | — | 1 | 5.19 |
| CHEMBL4463922 | — | — | 1 | 5.18 |
| CHEMBL4531566 | — | — | 1 | 5.18 |
| CHEMBL4280869 | — | — | 1 | 5.14 |
| CHEMBL4471917 | — | — | 1 | 4.92 |
| CHEMBL4532735 | — | — | 1 | 4.85 |
| CHEMBL4581637 | — | — | 1 | 4.77 |
| CHEMBL4529253 | — | — | 1 | - |
| CHEMBL4441277 | — | — | 1 | - |
| CHEMBL4535894 | — | — | 1 | - |
| CHEMBL4545702 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474029 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4461191 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4550191 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4466368 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4291913 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4288759 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4455962 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4454510 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4281296 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4453169 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4475877 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4438393 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4472917 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4473298 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4438951 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4563882 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4549947 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4514889 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4451895 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4443953 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4463922 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4531566 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4280869 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4471917 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4532735 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4581637 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4549918 | — | IC50 | - | — | - | |
| CHEMBL4530415 | — | IC50 | - | — | - | |
| CHEMBL4578639 | — | IC50 | - | — | - | |
| CHEMBL4540166 | — | IC50 | - | — | - | |
| CHEMBL4471489 | — | IC50 | - | — | - | |
| CHEMBL4443222 | — | IC50 | - | — | - | |
| CHEMBL4437367 | — | IC50 | - | — | - | |
| CHEMBL4586421 | — | IC50 | - | — | - | |
| CHEMBL4450408 | — | IC50 | - | — | - | |
| CHEMBL4445181 | — | IC50 | - | — | - | |
| CHEMBL4581611 | — | IC50 | - | — | - | |
| CHEMBL4445796 | — | IC50 | - | — | - | |
| CHEMBL4529253 | — | IC50 | - | — | - | |
| CHEMBL4563474 | — | IC50 | - | — | - | |
| CHEMBL4534109 | — | IC50 | - | — | - | |
| CHEMBL4553834 | — | IC50 | - | — | - | |
| CHEMBL4476701 | — | IC50 | - | — | - | |
| CHEMBL4449792 | — | IC50 | - | — | - | |
| CHEMBL4454421 | — | IC50 | - | — | - | |
| CHEMBL4450288 | — | IC50 | - | — | - | |
| CHEMBL4456393 | — | IC50 | - | — | - | |
| CHEMBL4545702 | — | IC50 | - | — | - | |
| CHEMBL4535894 | — | IC50 | - | — | - | |
| CHEMBL4441277 | — | IC50 | - | — | - |