Assay Detail
Binding
CHEMBL4428286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV integrase pre-incubated for 10 mins before addition of oligo-5'-biotin ATGTGGAAAATCTCTAGCA annealed with ACTGCTAGAGATTTTCCACAT 3'-Cy5) substrate
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.18 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50605 | — | — | 1 | 6.40 |
| CHEMBL4545702 | — | — | 1 | 6.00 |
| CHEMBL4475877 | — | — | 1 | 5.92 |
| CHEMBL4454510 | — | — | 1 | 5.89 |
| CHEMBL4581611 | — | — | 1 | 5.66 |
| CHEMBL4586421 | — | — | 1 | 5.36 |
| CHEMBL4471489 | — | — | 1 | 5.34 |
| CHEMBL4472002 | — | — | 1 | 5.15 |
| CHEMBL4473298 | — | — | 1 | 5.15 |
| CHEMBL4563474 | — | — | 1 | 4.92 |
| CHEMBL4437185 | — | — | 1 | 4.60 |
| CHEMBL4440667 | — | — | 1 | 4.52 |
| CHEMBL4474029 | — | — | 1 | 4.46 |
| CHEMBL4453169 | — | — | 1 | 4.36 |
| CHEMBL4549947 | — | — | 1 | 4.03 |
| CHEMBL4280869 | — | — | 1 | - |
| CHEMBL4451895 | — | — | 1 | - |
| CHEMBL4531566 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50605 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4545702 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4475877 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4454510 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4581611 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4586421 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4471489 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4472002 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4473298 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4563474 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4437185 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4440667 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4474029 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL4453169 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL4549947 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL4280869 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4451895 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4531566 | — | IC50 | > | 100000.0 | nM | - |