Assay Detail
Binding
CHEMBL4428340
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Inhibition of gamma secretase (unknown origin) mediated Notch signaling
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.62 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4476008 | — | — | 1 | 9.39 |
| CHEMBL520733 | SEMAGACESTAT | 3.0 | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4476008 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL520733 | SEMAGACESTAT | IC50 | = | 14.1 | nM | 7.85 |