Assay Detail
Binding
CHEMBL4428530
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CRT CVIET haplotype mutant in chloroquine-resistant Plasmodium falciparum K1 isolate MRA-159 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 relative to chloroquine alone
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum K1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Overcoming chloroquine resistance in malaria: Design, synthesis and structure-activity relationships of novel chemoreversal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.56 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4472492 | — | — | 1 | 6.77 |
| CHEMBL10780 | — | — | 1 | 6.70 |
| CHEMBL2205324 | — | — | 1 | 6.53 |
| CHEMBL4574174 | — | — | 1 | 6.46 |
| CHEMBL4449669 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4472492 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL10780 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2205324 | — | EC50 | = | 295.0 | nM | 6.53 |
| CHEMBL4574174 | — | EC50 | = | 343.0 | nM | 6.46 |
| CHEMBL4449669 | — | EC50 | = | 482.0 | nM | 6.32 |