Assay Detail
Binding
CHEMBL4428660
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Displacement of TAFMT from human pancreatic N-terminal His6-tagged glucokinase isoform 1 expressed in Escherichia coli BL21(DE3) by stopped-flow fluorometric method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 5.86 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4483049 | — | — | 1 | 6.40 |
| CHEMBL4534484 | — | — | 1 | 6.14 |
| CHEMBL1783734 | PIRAGLIATIN | 2.0 | 1 | 6.08 |
| CHEMBL4522750 | — | — | 1 | 5.70 |
| CHEMBL205627 | — | — | 1 | 5.48 |
| CHEMBL4457828 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4483049 | — | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL4534484 | — | Kd | = | 720.0 | nM | 6.14 |
| CHEMBL1783734 | PIRAGLIATIN | Kd | = | 830.0 | nM | 6.08 |
| CHEMBL4522750 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL205627 | — | Kd | = | 3300.0 | nM | 5.48 |
| CHEMBL4457828 | — | Kd | = | 4400.0 | nM | 5.36 |