Assay Detail
Binding
CHEMBL4428799
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Inhibition of PI3K p110alpha/p85 (unknown origin) using PIP2/ATP as substrate after 1 hr by kinase glo luminescent assay
29
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.01 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573339 | PI-103 | — | 1 | 8.13 |
| CHEMBL4555071 | — | — | 1 | 7.75 |
| CHEMBL4548366 | — | — | 1 | 7.64 |
| CHEMBL4522487 | — | — | 1 | 7.58 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 7.55 |
| CHEMBL4446205 | — | — | 2 | 7.51 |
| CHEMBL4442758 | — | — | 1 | 7.51 |
| CHEMBL4460361 | — | — | 2 | 7.50 |
| CHEMBL4453932 | — | — | 1 | 7.42 |
| CHEMBL4455733 | — | — | 1 | 7.23 |
| CHEMBL4540522 | — | — | 1 | 7.22 |
| CHEMBL4575186 | — | — | 1 | 7.21 |
| CHEMBL4457773 | — | — | 1 | 7.04 |
| CHEMBL4528366 | — | — | 1 | 6.93 |
| CHEMBL4457370 | — | — | 1 | 6.93 |
| CHEMBL4447129 | — | — | 1 | 6.89 |
| CHEMBL4555749 | — | — | 1 | 6.65 |
| CHEMBL4463279 | — | — | 1 | 6.43 |
| CHEMBL4593426 | — | — | 1 | 6.25 |
| CHEMBL4444148 | — | — | 1 | 6.05 |
| CHEMBL4462863 | — | — | 1 | 5.24 |
| CHEMBL4560668 | — | — | 1 | 5.02 |
| CHEMBL4517113 | — | — | 1 | - |
| CHEMBL4483565 | — | — | 1 | - |
| CHEMBL4438022 | — | — | 1 | - |
| CHEMBL4445769 | — | — | 1 | - |
| CHEMBL4450205 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573339 | PI-103 | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4555071 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4548366 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4522487 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4442758 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4446205 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4460361 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4446205 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4453932 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4455733 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4540522 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4575186 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4460361 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4457773 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4528366 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL4457370 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4447129 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4555749 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL4463279 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL4593426 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL4444148 | — | IC50 | = | 896.0 | nM | 6.05 |
| CHEMBL4462863 | — | IC50 | = | 5751.0 | nM | 5.24 |
| CHEMBL4560668 | — | IC50 | = | 9530.0 | nM | 5.02 |
| CHEMBL4483565 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4438022 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4517113 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4445769 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4450205 | — | IC50 | > | 10000.0 | nM | - |