Assay Detail
Binding
CHEMBL4428802
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Inhibition of PI3K p110delta/p85 (unknown origin) using PIP2/ATP as substrate after 1 hr by kinase glo luminescent assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.44 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4555071 | — | — | 1 | 7.89 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 7.21 |
| CHEMBL4446205 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4555071 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4446205 | — | IC50 | = | 61.0 | nM | 7.21 |