Assay Detail
Functional
CHEMBL4428804
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Antiproliferative activity against human MOLT4 cells after 72 hrs by CCK8 assay
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.93 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.70 |
| CHEMBL4457773 | — | — | 1 | 6.38 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 6.10 |
| CHEMBL4446205 | — | — | 2 | 6.01 |
| CHEMBL4548366 | — | — | 1 | 5.96 |
| CHEMBL4442758 | — | — | 1 | 5.96 |
| CHEMBL4540522 | — | — | 1 | 5.94 |
| CHEMBL4460361 | — | — | 2 | 5.92 |
| CHEMBL4455733 | — | — | 1 | 5.81 |
| CHEMBL4522487 | — | — | 1 | 5.75 |
| CHEMBL4555071 | — | — | 1 | 5.71 |
| CHEMBL4575186 | — | — | 1 | 5.71 |
| CHEMBL4453932 | — | — | 1 | 5.68 |
| CHEMBL4457370 | — | — | 1 | 5.60 |
| CHEMBL4463279 | — | — | 1 | 5.49 |
| CHEMBL4528366 | — | — | 1 | 5.39 |
| CHEMBL4444148 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4457773 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4446205 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4446205 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4548366 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4442758 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4540522 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4460361 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4455733 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4522487 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4555071 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4575186 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4453932 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4460361 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL4457370 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL4463279 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL4528366 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL4444148 | — | IC50 | - | — | - |