Assay Detail
Functional
CHEMBL4428809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SK-BR-3 cells after 72 hrs by CCK8 assay
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.70 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.30 |
| CHEMBL4446205 | — | — | 2 | 5.80 |
| CHEMBL4548366 | — | — | 1 | 5.80 |
| CHEMBL4442758 | — | — | 1 | 5.79 |
| CHEMBL4522487 | — | — | 1 | 5.57 |
| CHEMBL4575186 | — | — | 1 | 5.46 |
| CHEMBL4453932 | — | — | 1 | 5.43 |
| CHEMBL4460361 | — | — | 2 | 5.37 |
| CHEMBL4555071 | — | — | 1 | 5.32 |
| CHEMBL4528366 | — | — | 1 | 5.18 |
| CHEMBL4463279 | — | — | 1 | - |
| CHEMBL4455733 | — | — | 1 | - |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | - |
| CHEMBL4444148 | — | — | 1 | - |
| CHEMBL4457370 | — | — | 1 | - |
| CHEMBL4540522 | — | — | 1 | - |
| CHEMBL4457773 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4446205 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4548366 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4442758 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4522487 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL4575186 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL4453932 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4460361 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL4555071 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL4528366 | — | IC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL2017974 | BUPARLISIB | IC50 | - | — | - | |
| CHEMBL4463279 | — | IC50 | - | — | - | |
| CHEMBL4455733 | — | IC50 | - | — | - | |
| CHEMBL4460361 | — | IC50 | - | — | - | |
| CHEMBL4444148 | — | IC50 | - | — | - | |
| CHEMBL4457370 | — | IC50 | - | — | - | |
| CHEMBL4446205 | — | IC50 | - | — | - | |
| CHEMBL4540522 | — | IC50 | - | — | - | |
| CHEMBL4457773 | — | IC50 | - | — | - |