Assay Detail
Binding
CHEMBL4428870
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Inhibition of factor 12a (unknown origin) using Ac-QRFRpNA as substrate incubated for 30 mins measured for 7 mins by morrison plot analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.25 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4440685 | — | — | 1 | 6.96 |
| CHEMBL4577000 | — | — | 1 | 6.75 |
| CHEMBL4590811 | — | — | 1 | 6.31 |
| CHEMBL4449980 | — | — | 1 | 6.29 |
| CHEMBL4483694 | — | — | 1 | 6.12 |
| CHEMBL4446504 | — | — | 1 | 5.67 |
| CHEMBL4470708 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4440685 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4577000 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL4590811 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL4449980 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL4483694 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL4446504 | — | Ki | = | 2160.0 | nM | 5.67 |
| CHEMBL4470708 | — | Ki | = | 2390.0 | nM | 5.62 |