Assay Detail
Binding
CHEMBL4428875
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Inhibition of trypsin (unknown origin) using Bz-FVRpNA as substrate incubated for 30 mins measured for 7 mins by morrison plot analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.21 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4483694 | — | — | 1 | 9.80 |
| CHEMBL4440685 | — | — | 1 | 8.16 |
| CHEMBL4449980 | — | — | 1 | 5.65 |
| CHEMBL4590811 | — | — | 1 | 5.21 |
| CHEMBL4446504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4483694 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL4440685 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL4449980 | — | Ki | = | 2240.0 | nM | 5.65 |
| CHEMBL4590811 | — | Ki | = | 6240.0 | nM | 5.21 |
| CHEMBL4446504 | — | Ki | > | 10000.0 | nM | - |