Assay Detail
Functional
CHEMBL4429041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Protection against tunicamycin induced endoplasmic reticulum stress in rat INS-1 cells assessed as increase in cell viability after 3 days by CellTiter-Glo assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | INS1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 6.07 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441759 | — | — | 1 | 6.85 |
| CHEMBL4441835 | — | — | 1 | 6.77 |
| CHEMBL4585838 | — | — | 1 | 6.68 |
| CHEMBL4536152 | — | — | 1 | 6.64 |
| CHEMBL4441051 | — | — | 1 | 6.51 |
| CHEMBL4565474 | — | — | 1 | 6.51 |
| CHEMBL4558368 | — | — | 1 | 6.47 |
| CHEMBL4449190 | — | — | 1 | 6.44 |
| CHEMBL4575691 | — | — | 1 | 6.33 |
| CHEMBL4436219 | — | — | 1 | 6.32 |
| CHEMBL4458749 | — | — | 1 | 6.29 |
| CHEMBL4456642 | — | — | 1 | 6.25 |
| CHEMBL4470746 | — | — | 1 | 6.19 |
| CHEMBL4565123 | — | — | 1 | 6.18 |
| CHEMBL4566645 | — | — | 1 | 6.11 |
| CHEMBL4518107 | — | — | 1 | 6.11 |
| CHEMBL4538777 | — | — | 1 | 6.10 |
| CHEMBL4590095 | — | — | 1 | 5.98 |
| CHEMBL4461395 | — | — | 1 | 5.94 |
| CHEMBL4436000 | — | — | 1 | 5.85 |
| CHEMBL4446442 | — | — | 1 | 5.84 |
| CHEMBL4434905 | — | — | 1 | 5.84 |
| CHEMBL4446218 | — | — | 1 | 5.82 |
| CHEMBL4590000 | — | — | 1 | 5.80 |
| CHEMBL4443334 | — | — | 1 | 5.77 |
| CHEMBL4450946 | — | — | 1 | 5.73 |
| CHEMBL4437902 | — | — | 1 | 5.73 |
| CHEMBL4546524 | — | — | 1 | 5.73 |
| CHEMBL4451272 | — | — | 1 | 5.67 |
| CHEMBL4457865 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441759 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4441835 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4585838 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4536152 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4441051 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4565474 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4558368 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4449190 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4575691 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4436219 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4458749 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4456642 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4470746 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4565123 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4518107 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4566645 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4538777 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4590095 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4461395 | — | EC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4436000 | — | EC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4446442 | — | EC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4434905 | — | EC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL4446218 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4590000 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4443334 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4450946 | — | EC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4437902 | — | EC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4546524 | — | EC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4451272 | — | EC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL4457865 | — | EC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL4442008 | — | EC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL4468078 | — | EC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL4578742 | — | EC50 | = | 4050.0 | nM | 5.39 |