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Assay Detail

CHEMBL4429089

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HCV genotype 1a replicons NS5A infected in human Huh7 cells by luciferase reporter gene assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus subtype 1a
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Nonstructural protein 5A (CHEMBL3307224)
Type SINGLE PROTEIN
Organism Hepatitis C virus

Publication

Discovery of ravidasvir (PPI-668) as a potent pan-genotypic HCV NS5A inhibitor.
Zhong M, Peng E, Huang N, Huang Q, Huq A, Lau M, Colonno R, Li L.
Bioorg Med Chem Lett (2016) 26 : 4508 -4512
PubMed 27506559 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 26 9.52 10.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4469447 1 10.30
CHEMBL4580319 1 10.30
CHEMBL4473534 1 10.15
CHEMBL4587166 1 10.10
CHEMBL4590699 1 10.10
CHEMBL4462540 1 10.00
CHEMBL4446538 1 9.96
CHEMBL4461107 1 9.96
CHEMBL4443067 1 9.92
CHEMBL4578947 1 9.89
CHEMBL4562653 1 9.89
CHEMBL4442791 1 9.85
CHEMBL4465723 1 9.66
CHEMBL4448643 1 9.64
CHEMBL4537091 1 9.59
CHEMBL4436038 1 9.40
CHEMBL4451714 1 9.37
CHEMBL4582393 1 9.22
CHEMBL4435313 1 9.18
CHEMBL4563619 1 9.17
CHEMBL4475469 1 8.92
CHEMBL4442594 1 8.89
CHEMBL4467806 1 8.69
CHEMBL4546536 1 8.54
CHEMBL4448546 1 7.40
CHEMBL4442126 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4469447 EC50 = 0.05 nM 10.30
CHEMBL4580319 EC50 = 0.05 nM 10.30
CHEMBL4473534 EC50 = 0.07 nM 10.15
CHEMBL4587166 EC50 = 0.08 nM 10.10
CHEMBL4590699 EC50 = 0.08 nM 10.10
CHEMBL4462540 EC50 = 0.1 nM 10.00
CHEMBL4446538 EC50 = 0.11 nM 9.96
CHEMBL4461107 EC50 = 0.11 nM 9.96
CHEMBL4443067 EC50 = 0.12 nM 9.92
CHEMBL4578947 EC50 = 0.13 nM 9.89
CHEMBL4562653 EC50 = 0.13 nM 9.89
CHEMBL4442791 EC50 = 0.14 nM 9.85
CHEMBL4465723 EC50 = 0.22 nM 9.66
CHEMBL4448643 EC50 = 0.23 nM 9.64
CHEMBL4537091 EC50 = 0.26 nM 9.59
CHEMBL4436038 EC50 = 0.4 nM 9.40
CHEMBL4451714 EC50 = 0.43 nM 9.37
CHEMBL4582393 EC50 = 0.6 nM 9.22
CHEMBL4435313 EC50 = 0.66 nM 9.18
CHEMBL4563619 EC50 = 0.68 nM 9.17
CHEMBL4475469 EC50 = 1.2 nM 8.92
CHEMBL4442594 EC50 = 1.3 nM 8.89
CHEMBL4467806 EC50 = 2.03 nM 8.69
CHEMBL4546536 EC50 = 2.85 nM 8.54
CHEMBL4448546 EC50 = 39.7 nM 7.40
CHEMBL4442126 EC50 > 100.0 nM -