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Assay Detail

CHEMBL4429090

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HCV genotype 1b replicons NS5A infected in human Huh7 cells by luciferase reporter gene assay
ChEMBL ↗
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus subtype 1b
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Nonstructural protein 5A (CHEMBL3307224) ↗
Type SINGLE PROTEIN
Organism Hepatitis C virus

Publication

Discovery of ravidasvir (PPI-668) as a potent pan-genotypic HCV NS5A inhibitor.
Zhong M, Peng E, Huang N, Huang Q, Huq A, Lau M, Colonno R, Li L.
Bioorg Med Chem Lett (2016) 26 : 4508 -4512
PubMed 27506559 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 26 10.48 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4443067 — — 1 11.00
CHEMBL4461107 — — 1 10.96
CHEMBL4465723 — — 1 10.85
CHEMBL4446538 — — 1 10.82
CHEMBL4473534 — — 1 10.82
CHEMBL4435313 — — 1 10.72
CHEMBL4436038 — — 1 10.68
CHEMBL4462540 — — 1 10.66
CHEMBL4469447 — — 1 10.64
CHEMBL4587166 — — 1 10.60
CHEMBL4448643 — — 1 10.59
CHEMBL4590699 — — 1 10.52
CHEMBL4467806 — — 1 10.39
CHEMBL4537091 — — 1 10.38
CHEMBL4442594 — — 1 10.34
CHEMBL4578947 — — 1 10.33
CHEMBL4448546 — — 1 10.30
CHEMBL4475469 — — 1 10.28
CHEMBL4563619 — — 1 10.28
CHEMBL4442791 — — 1 10.14
CHEMBL4546536 — — 1 10.13
CHEMBL4562653 — — 1 9.95
CHEMBL4451714 — — 1 9.72
CHEMBL4442126 — — 1 -
CHEMBL4582393 — — 1 -
CHEMBL4580319 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4443067 — EC50 = 0.01 nM 11.00
CHEMBL4461107 — EC50 = 0.011 nM 10.96
CHEMBL4465723 — EC50 = 0.014 nM 10.85
CHEMBL4446538 — EC50 = 0.015 nM 10.82
CHEMBL4473534 — EC50 = 0.015 nM 10.82
CHEMBL4435313 — EC50 = 0.019 nM 10.72
CHEMBL4436038 — EC50 = 0.021 nM 10.68
CHEMBL4462540 — EC50 = 0.022 nM 10.66
CHEMBL4469447 — EC50 = 0.023 nM 10.64
CHEMBL4587166 — EC50 = 0.025 nM 10.60
CHEMBL4448643 — EC50 = 0.026 nM 10.59
CHEMBL4590699 — EC50 = 0.03 nM 10.52
CHEMBL4467806 — EC50 = 0.041 nM 10.39
CHEMBL4537091 — EC50 = 0.042 nM 10.38
CHEMBL4442594 — EC50 = 0.046 nM 10.34
CHEMBL4578947 — EC50 = 0.047 nM 10.33
CHEMBL4448546 — EC50 = 0.05 nM 10.30
CHEMBL4475469 — EC50 = 0.052 nM 10.28
CHEMBL4563619 — EC50 = 0.053 nM 10.28
CHEMBL4442791 — EC50 = 0.073 nM 10.14
CHEMBL4546536 — EC50 = 0.074 nM 10.13
CHEMBL4562653 — EC50 = 0.113 nM 9.95
CHEMBL4451714 — EC50 = 0.19 nM 9.72
CHEMBL4442126 — EC50 > 3.7 nM -
CHEMBL4582393 — EC50 = 0.009 nM -
CHEMBL4580319 — EC50 = 0.003 nM -