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Assay Detail

CHEMBL4429339

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of GST-tagged Trypanosoma brucei ERK8 expressed in Escherichia coli using recombinant myelin basic protein as substrate after 30 mins in presence of 32P-gamma-ATP by Michaelis-Menten analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma brucei
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor.
Valenciano AL, Ramsey AC, Santos WL, Mackey ZB.
Bioorg Med Chem (2016) 24 : 4647 -4651
PubMed 27519462 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.90 5.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1774055 1 5.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1774055 Ki = 1250.0 nM 5.90