Assay Detail

CHEMBL4429350

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Functional

Antiproliferative activity against human MCF7 cells after 5 days by coulter counter analysis

ChEMBL ↗

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Target

MCF7 (CHEMBL387) ↗

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Primary target MCF7

CHEMBL387

Anchored from Assay target.

Protein identity MCF7

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MCF7
Confidence	1 — Organism
Curated By	Autocuration

Target

MCF7 (CHEMBL387) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD).

Liu J, Zheng S, Akerstrom VL, Yuan C, Ma Y, Zhong Q, Zhang C, Zhang Q, Guo S, Ma P, Skripnikova EV, Bratton MR, Pannuti A, Miele L, Wiese TE, Wang G.
J Med Chem (2016) 59 : 8134 -8140
PubMed 27529700 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	8.60	8.82

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1358	FULVESTRANT	4.0	1	8.82
CHEMBL4526356	ZB-716	1.0	1	8.49
CHEMBL489	AFIMOXIFENE	3.0	1	8.48

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1358	FULVESTRANT	IC50	=	1.5	nM	8.82
CHEMBL4526356	ZB-716	IC50	=	3.2	nM	8.49
CHEMBL489	AFIMOXIFENE	IC50	=	3.3	nM	8.48