Assay Detail
Functional
CHEMBL4429519
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Antimalarial activity against chloroquine/mefloquine-sensitive Plasmodium falciparum 3D7 infected-erythrocytes assessed as parasite growth inhibition after 48 to 54 hrs by SYBR green 1-based replication method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Parallel inhibition of amino acid efflux and growth of erythrocytic Plasmodium falciparum by mefloquine and non-piperidine analogs: Implication for the mechanism of antimalarial action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.44 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129788 | — | — | 1 | 9.92 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.22 |
| CHEMBL4545745 | — | — | 1 | 8.42 |
| CHEMBL3229607 | — | — | 1 | 8.38 |
| CHEMBL598534 | — | — | 1 | 8.33 |
| CHEMBL602912 | — | — | 1 | 8.31 |
| CHEMBL4521687 | — | — | 1 | 8.23 |
| CHEMBL598533 | — | — | 1 | 8.13 |
| CHEMBL605788 | — | — | 1 | 8.07 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 8.04 |
| CHEMBL4586469 | — | — | 1 | 7.47 |
| CHEMBL4441697 | — | — | 1 | 7.31 |
| CHEMBL4435954 | — | — | 1 | 6.96 |
| CHEMBL4483516 | — | — | 1 | 6.92 |
| CHEMBL4435208 | — | — | 1 | 6.85 |
| CHEMBL1822318 | — | — | 1 | 6.62 |
| CHEMBL598930 | — | — | 1 | 6.47 |
| CHEMBL4448380 | — | — | 1 | 6.46 |
| CHEMBL4557449 | — | — | 1 | 5.80 |
| CHEMBL604953 | — | — | 1 | 5.70 |
| CHEMBL4532597 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129788 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4545745 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3229607 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL598534 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL602912 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4521687 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL598533 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL605788 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4586469 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4441697 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4435954 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4483516 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4435208 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1822318 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL598930 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4448380 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4557449 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL604953 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4532597 | — | IC50 | = | 22000.0 | nM | 4.66 |